Chorionic villus sampling is a technique in which fetally derived
chorionic villus material is obtained transcervically with a
flexible catheter between 10 and 12 weeks’ gestation or by
transabdominal puncture and aspiration at any time up to
term. Both methods are performed under ultrasound
guidance, and fetal viability is checked before and after the
procedure. The risk of miscarriage related to sampling in the
first trimester in experienced hands is probably about 1–2%
higher than the rate of spontaneous abortions at this time.
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